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Hollis Showalter
ann arbor, Michigan
Organic and heterocyclic synthesis methodologies
Synthetic modification of natural products
Designing in physicochemical properties to high-throughput screen hits that confer "drugability" (e.g., conformity to Lipinski rules, absence of toxicophores)
Development of structure-activity relationships (SAR) to derive compounds with optimal pharmacokinetic and metabolic profiles toward the initiation of in vivo studies
Medicinal chemistry of inhibitors of protein kinases, principally PKC, EGFr, PDGFr, FGFr, VEGFr, c-Src, and therapeutic application to proliferative processes (cancer, restenosis, angiogenesis, and inflammatory diseases)
Medicinal chemistry of inhibitors of deubiquitinases and application to haematologic cancers
Medicinal chemistry of antibacterial agents; new agents for tuberculosis
Early-stage drug development
Chemistry
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